The murine AIDS virus Gag precursor protein binds to the SH3 domain of c-Abl.
J Virol
; 71(4): 2615-20, 1997 Apr.
Article
em En
| MEDLINE
| ID: mdl-9060613
ABSTRACT
The Pr60gag protein of the murine AIDS (MAIDS) defective virus promotes the proliferation of the infected target B cells and is responsible for inducing a severe immunodeficiency disease. Using the yeast two-hybrid system, we identified the SH3 domain of c-Abl as interacting with the proline-rich p12 domain of Pr60gag. The two proteins were shown to associate in vitro and in vivo in MAIDS virus-infected B cells. Overexpression of Pr60(gag) in these cells led to a detectable increase of the levels of c-Abl protein and to its translocation at the membrane. These results suggest that this viral protein serves as a docking site for signaling molecules and that c-Abl may be involved in the proliferation of infected B cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Precursores de Proteínas
/
Produtos do Gene gag
/
Proteínas Proto-Oncogênicas c-abl
/
Vírus da Leucemia Murina
/
Domínios de Homologia de src
Limite:
Animals
Idioma:
En
Revista:
J Virol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Canadá