Effect of radiotherapy and chemotherapy on composition of tumor membrane phospholipids.
Lipids
; 32(1): 45-9, 1997 Jan.
Article
em En
| MEDLINE
| ID: mdl-9075192
ABSTRACT
Phospholipid extracts were made of a murine mammary adenocarcinoma implanted in the dorsum of the foot of C3H/He mice before and 96 h after 17 Gy irradiation or 150 mg/kg cyclophosphamide. Extracts of untreated tumors, which had grown for a further 96 h, were also studied. Although previous studies have shown significant changes in the precursors and catabolites of phosphatidylcholine and phosphatidylethanolamine following therapy, 31P nuclear magnetic resonance analysis of extracts showed no changes in these membrane constituents and other observed phospholipid species. A significant decrease in 1-alkyl-2-acyl-sn-glycero-3-phosphocholine, however, was observed 96 h following cyclophosphamide treatment.
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Base de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
/
Adenocarcinoma
/
Antineoplásicos Alquilantes
/
Ciclofosfamida
/
Lipídeos de Membrana
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Lipids
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos