Effects of tumor necrosis factor on receptor-mediated endocytosis and barrier functions of bovine brain capillary endothelial cell monolayers.
J Neuroimmunol
; 74(1-2): 173-84, 1997 Apr.
Article
em En
| MEDLINE
| ID: mdl-9119971
ABSTRACT
Tumor necrosis factor alpha (TNF-alpha) plays a crucial role in the pathogenesis of the central nervous system infections. In an in vitro reconstructed blood-brain barrier model, a significant dysregulation of receptor mediated endocytosis of low density lipoproteins (LDL) and transferrin (Tf) is demonstrated at delayed phase of direct TNF-alpha activation. Concomitant with the increase in LDL uptake, we demonstrate a decrease of Tf-receptor mediated endocytosis. The potential role of TNF action in the differential or opposite routing of macromolecules is also characterized by a stimulation of their transcytosis. These findings may provide a new insight into the inflammatory effect of TNF-alpha on brain capillary endothelial cells.
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Base de dados:
MEDLINE
Assunto principal:
Receptores da Transferrina
/
Endotélio Vascular
/
Barreira Hematoencefálica
/
Circulação Cerebrovascular
/
Fator de Necrose Tumoral alfa
/
Endocitose
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
França