Gene expression profiles in normal and cancer cells.
Science
; 276(5316): 1268-72, 1997 May 23.
Article
em En
| MEDLINE
| ID: mdl-9157888
ABSTRACT
As a step toward understanding the complex differences between normal and cancer cells in humans, gene expression patterns were examined in gastrointestinal tumors. More than 300,000 transcripts derived from at least 45,000 different genes were analyzed. Although extensive similarity was noted between the expression profiles, more than 500 transcripts that were expressed at significantly different levels in normal and neoplastic cells were identified. These data provide insight into the extent of expression differences underlying malignancy and reveal genes that may prove useful as diagnostic or prognostic markers.
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Base de dados:
MEDLINE
Assunto principal:
Expressão Gênica
/
Fenômenos Fisiológicos do Sistema Digestório
/
Neoplasias Gastrointestinais
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos