Sensitization to the behavioral effects of cocaine: modulation by dynorphin and kappa-opioid receptor agonists.
Pharmacol Biochem Behav
; 57(3): 449-55, 1997 Jul.
Article
em En
| MEDLINE
| ID: mdl-9218269
ABSTRACT
Several lines of evidence suggest an involvement of the mesolimbic dopamine (DA) system in the mediation of psychostimulant-induced sensitization. It is also apparent that endogenous opioid peptide systems can modulate the activity of this same DA system. Psychostimulant-induced alterations in opioid peptide gene expression have also been reported. In this review, evidence will be presented that demonstrates that the administration of kappa-opioid agonists can prevent the initiation of behavioral sensitization to cocaine and that such treatment is also effective in preventing alterations in mesolimbic DA neurotransmission that occur as a consequence of repeated cocaine administration. The putative role of opioid-DA interactions in the modulation of psychostimulant-induced sensitization will also be discussed.
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Base de dados:
MEDLINE
Assunto principal:
Dinorfinas
/
Cocaína
/
Receptores Opioides kappa
/
Locomoção
Limite:
Animals
Idioma:
En
Revista:
Pharmacol Biochem Behav
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos