Large scale and clinical grade purification of syndecan-1+ malignant plasma cells.
J Immunol Methods
; 205(1): 73-9, 1997 Jun 23.
Article
em En
| MEDLINE
| ID: mdl-9236917
ABSTRACT
For cancer immunotherapy, it is usually necessary to obtain a large number of tumor cells from patients. We have previously reported that syndecan-I is present only on malignant plasma cells in samples from patients with multiple myelomatosis. We report here that this antigen is cleaved by chymopapain. This makes it possible to develop a rapid and clinical grade procedure to purify large numbers of myeloma cells using anti-syndecan-1 mAb, magnetic beads and chymopapain.
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Base de dados:
MEDLINE
Assunto principal:
Plasmócitos
/
Proteoglicanas
/
Glicoproteínas de Membrana
/
Separação Imunomagnética
/
Mieloma Múltiplo
Limite:
Humans
Idioma:
En
Revista:
J Immunol Methods
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
França