Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.
Science
; 278(5336): 275-9, 1997 Oct 10.
Article
em En
| MEDLINE
| ID: mdl-9323204
ABSTRACT
Substance P is released in the spinal cord in response to painful stimuli, but its role in nociceptive signaling remains unclear. When a conjugate of substance P and the ribosome-inactivating protein saporin was infused into the spinal cord, it was internalized and cytotoxic to lamina I spinal cord neurons that express the substance P receptor. This treatment left responses to mild noxious stimuli unchanged, but markedly attenuated responses to highly noxious stimuli and mechanical and thermal hyperalgesia. Thus, lamina I spinal cord neurons that express the substance P receptor play a pivotal role in the transmission of highly noxious stimuli and the maintenance of hyperalgesia.
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Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Substância P
/
Imunotoxinas
/
Receptores da Neurocinina-1
/
Manejo da Dor
/
Hiperalgesia
/
Neurônios
/
N-Glicosil Hidrolases
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos