A comparison of etodolac (Ultradol) with acetaminophen plus codeine (Tylenol #3) in controlling post-surgical pain in vasectomy patients.
Curr Med Res Opin
; 13(10): 555-63, 1997.
Article
em En
| MEDLINE
| ID: mdl-9327190
ABSTRACT
The efficacy and safety of etodolac (Ultradol) and acetaminophen plus codeine [A + C (Tylenol #3)] in controlling post-surgical pain were compared in an open-label, randomized, parallel-group outpatient study. Patients who were voluntarily having a vasectomy performed for sterilization were assigned to receive either etodolac 200 mg (20 patients) or A + C (20 patients). All medication was taken as required for up to 7 days. Efficacy assessments were made at 1, 6 and 24 hours after surgery and included pain measurement (Likert Visual Analogue scale), patient and physician global assessments and time to analgesic relief. Safety assessments were made throughout the study and included vital signs and adverse event monitoring. Results of the study indicated that patients taking etodolac were more likely to say they could return to work 24 hours after their vasectomy (p = 0.04). There were no other statistically significant differences between the two groups of patients. The results from this study indicate that etodolac and A + C are equally efficacious and well-tolerated for the control of post-vasectomy pain and that patients may observe an increased benefit with etodolac by being able to return to work sooner.
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Base de dados:
MEDLINE
Assunto principal:
Dor Pós-Operatória
/
Vasectomia
/
Anti-Inflamatórios não Esteroides
/
Etodolac
/
Codeína
/
Analgésicos não Narcóticos
/
Analgésicos Opioides
/
Acetaminofen
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Curr Med Res Opin
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Canadá