Evaluation of fluorine-18-BPA-fructose for boron neutron capture treatment planning.
J Nucl Med
; 38(11): 1762-7, 1997 Nov.
Article
em En
| MEDLINE
| ID: mdl-9374349
ABSTRACT
UNLABELLED Boron neutron capture therapy (BNCT) using 4-[10B]boronophenylalanine-fructose (BPA-Fr) is in Phase II clinical trials to validate BNCT as a treatment for glioblastoma multiforme and melanoma. Successful BNCT depends on knowledge of the distribution of boron-containing agents in both tumor and normal tissue as currently determined by chemical confirmation of boron deposition in surgically removed malignant tissue before BNCT. METHODS:
We used PET to noninvasively obtain in vivo information on the pharmacokinetics of the 18F-labeled analog of BPA-Fr in two patients with glioblastoma multiforme. Time-activity curves generated from the bolus injection of 18F-BPA-Fr were coinvolved to simulate a continuous infusion used for BNCT therapy.RESULTS:
Distribution of 18F-BPA-Fr by PET was found to be consistent with tumor as identified by MR imaging. The 18F-BPA-Fr tumor-to-normal brain uptake ratio was 1.9 in Patient 1 and 3.1 in Patient 2 at 52 min after injection. The 18F-BPA-Fr uptake ratio in glioblastoma paralleled that of nonlabeled BPA-Fr seen in patients as previously determined by boron analysis of human glioblastoma tissue obtained from pre-BNCT surgical biopsy.CONCLUSION:
Knowledge of the biodistribution of BPA-Fr enables pre-BNCT calculation of expected tissue dosimetry for a selected dose of BPA-Fr at a specific neutron exposure. Fluorine-18-BPA-Fr PET is capable of providing in vivo BPA-Fr biodistribution data that may prove valuable for patient selection and pre-BNCT treatment planning.
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Base de dados:
MEDLINE
Assunto principal:
Fenilalanina
/
Radiossensibilizantes
/
Neoplasias Encefálicas
/
Compostos de Boro
/
Radioisótopos de Flúor
/
Tomografia Computadorizada de Emissão
/
Terapia por Captura de Nêutron de Boro
/
Glioblastoma
/
Frutose
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Nucl Med
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos