CD30+ lymphocytes in chronic gingivitis from HIV-positive patients: a pilot study.
J Periodontol
; 68(9): 881-3, 1997 Sep.
Article
em En
| MEDLINE
| ID: mdl-9379333
ABSTRACT
Th2 type lymphocytes are characterized by high expression of CD30 glycoprotein. Increased serum levels of CD30 and Th2 IL-4 producing T-cells are found during AIDS progression. Since HIV-positive patients are more susceptible to periodontal disease, quantitative analysis of positive cells for the CD30 receptor in chronic gingivitis of both HIV-infected and non-infected patients (NSG) would help to clarify the immunoregulation of HIV-associated periodontal diseases. The purpose of this study was to evaluate CD30+ lymphocytes in gingival biopsies from sites exhibiting chronic gingivitis on HIV-positive patients (CG-HIV) and NSG. A biotin-streptavidin amplified system was used for identification of the CD30 receptor. The results demonstrated increased proportions of Th2 cells in CG-HIV as compared to NSG. Additional studies are necessary to understand the importance of these cells to the biological activity or inactivity of the disease.
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Base de dados:
MEDLINE
Assunto principal:
Soropositividade para HIV
/
Antígeno Ki-1
/
Células Th1
/
Gengivite
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Periodontol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Brasil