Your browser doesn't support javascript.
loading
Embryonic expression of the mRNA for the rat homologue of the fusin/CXCR-4 HIV-1 co-receptor.
Jazin, E E; Söderström, S; Ebendal, T; Larhammar, D.
Afiliação
  • Jazin EE; Department of Medical Genetics, Uppsala University, Sweden. elena.jazin@medgen.uu.se
J Neuroimmunol ; 79(2): 148-54, 1997 Nov.
Article em En | MEDLINE | ID: mdl-9394787
We have previously cloned a human receptor recently shown to be a cofactor for entry of T-tropic HIV-1 strains into CD4+ cells, now named fusin. Stromal derived factor-1 (SDF-1) is an endogenous ligand for fusin, also called CXCR-4. Here we show the distribution of fusin/CXCR-4 mRNA during ontogeny in the rat. The onset of mRNA expression is around embryonic day 9 and the mRNA expression is high in the thymus as well as proliferative areas of the brain during development. Our results suggest: (1) that fusin/CXCR-4 might have a dual role in both brain development and the immune system; (2) that SDF-1 has a role in brain development or that additional physiological ligands exist for this receptor; (3) co-expression of CD4 and fusin/CXCR-4 may make fetuses susceptible to HIV infection during development.
Assuntos
Buscar no Google
Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Receptores CXCR4 / Embrião de Mamíferos Limite: Animals / Humans Idioma: En Revista: J Neuroimmunol Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Suécia
Buscar no Google
Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Receptores CXCR4 / Embrião de Mamíferos Limite: Animals / Humans Idioma: En Revista: J Neuroimmunol Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Suécia