Interferon-induced growth arrest is mediated by membrane structural changes.
J Interferon Cytokine Res
; 17(11): 701-6, 1997 Nov.
Article
em En
| MEDLINE
| ID: mdl-9402108
ABSTRACT
Interferon-gamma (IFN-gamma) is an immunomodulator shown to augment the expression of major histocompatibility (MHC) class I/class II antigens on the cell surface. In previous studies, we have demonstrated that the enhanced expression of these antigens on the cell surface is in part due to IFN-gamma-mediated abrogation of antigen shedding. In this study, we demonstrate that IFN-gamma induces structural changes in the cell membrane by altering the cholesterol/phospholipid ratio. Furthermore, such changes not only mediate enhanced expression of antigen on the cell surface but may drive the cells to growth arrest and apoptosis. These results were obtained by employing x-ray diffraction, electron microscopy, and DNA analysis.
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Base de dados:
MEDLINE
Assunto principal:
Adjuvantes Imunológicos
/
Interferon gama
/
Fluidez de Membrana
Limite:
Humans
Idioma:
En
Revista:
J Interferon Cytokine Res
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos