Effects of cyclosporin A on hepatitis C virus infection in bone marrow transplant patients. Bone Marrow Transplantation Team.
Bone Marrow Transplant
; 20(11): 993-5, 1997 Dec.
Article
em En
| MEDLINE
| ID: mdl-9422481
ABSTRACT
The hepatitis C virus (HCV) infection has, in general, been considered not to affect liver function severely during the course of bone marrow transplantation (BMT) except for late hepatitis which coincided with a decrease in immunosuppressive therapy. We examined serial sera of two patients with positive HCV antibody who underwent allogeneic BMT and found that while the dose of cyclosporin A tapered off, the serum concentration of HCV core protein increased before the occurrence of hepatitis. This suggests that viral reactivation and growth might be one of the important mechanisms of hepatitis after BMT in patients with positive HCV antibody.
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Base de dados:
MEDLINE
Assunto principal:
Anticorpos Anti-Hepatite
/
Transplante de Medula Óssea
/
Ciclosporina
/
Hepatite C Crônica
/
Imunossupressores
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Bone Marrow Transplant
Assunto da revista:
TRANSPLANTE
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Japão