Enantioselective analysis of albendazole sulfoxide in plasma using the chiral stationary phase.
Chirality
; 9(8): 722-6, 1997.
Article
em En
| MEDLINE
| ID: mdl-9435097
ABSTRACT
We present a method for the enantioselective analysis of albendazole sulfoxide (ABZSO) in plasma for application in clinical pharmacokinetic studies. ABZSO enantiomers were separated on a 5-micron Chiralcel OB-H column (4.6 x 150 mm) using hexaneethanol (937, v/v) as the mobile phase and fluorescence detection. ABZSO was extracted with chloroformisopropanol (82, v/v) from 500-microliter aliquots of acidified plasma, with full drug recovery. The proposed method presented quantitation limits of 20 ng/ml for (-)ABZSO and 50 ng/ml for (+)ABZSO and was linear up to a concentration of 5,000 ng/ml of each enantiomer.
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Base de dados:
MEDLINE
Assunto principal:
Albendazol
/
Anti-Helmínticos
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Chirality
Assunto da revista:
BIOLOGIA MOLECULAR
/
QUIMICA
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Brasil