Engineering proteins that bind to cell surface carbohydrates.
Clin Chim Acta
; 266(1): 13-22, 1997 Oct 09.
Article
em En
| MEDLINE
| ID: mdl-9435984
ABSTRACT
Carbohydrate residues covalently linked to plasma membrane proteins and lipids often provide specific markers at the cell surface. Traditionally such carbohydrate structures have been identified using antibodies and lectins. However problems of affinity and lack of specificity have restricted their usefulness. Protein engineering offers a way round these difficulties. In the case of some specialised cell surface carbohydrate structures, such as polysialic acid, enzymes may be useful analytical tools. Endosialidases specific for polysialic acid have recently been cloned and sequenced.
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Base de dados:
MEDLINE
Assunto principal:
Engenharia de Proteínas
/
Metabolismo dos Carboidratos
Limite:
Humans
Idioma:
En
Revista:
Clin Chim Acta
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Reino Unido