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Suppression of the number of aberrant crypt foci of rat colorectum by ingestion of sugar beet fiber regardless of administration of anti-asialo GM1.
Ishizuka, S; Kasai, T.
Afiliação
  • Ishizuka S; Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan. zuka@chem.agr.hokudai.ac.jp
Cancer Lett ; 121(1): 39-43, 1997 Dec 16.
Article em En | MEDLINE | ID: mdl-9459172
ABSTRACT
Anti-asialo GM1 serum (AGM1) reduces natural killer (NK) activity in vitro and in vivo. We investigated the effect of ingestion of sugar beet fiber (SBF) on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) and whether the effect was maintained under NK-reducing conditions by AGM1 injection. The ingestion of SBF decreased the number of ACF in the colorectum at 4 weeks after treatment with DMH. Dietary SBF had a suppressive effect on the formation of ACF regardless of the administration of AGM1. These results suggest that the suppressive effect created by the ingestion of SBF may overwhelm the effect of AGM1 treatment on ACF formation.
Assuntos
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Base de dados: MEDLINE Assunto principal: Lesões Pré-Cancerosas / Fibras na Dieta / Pólipos do Colo / Neoplasias do Colo / Chenopodiaceae / Gangliosídeo G(M1) / Mucosa Intestinal Limite: Animals Idioma: En Revista: Cancer Lett Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Japão
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Base de dados: MEDLINE Assunto principal: Lesões Pré-Cancerosas / Fibras na Dieta / Pólipos do Colo / Neoplasias do Colo / Chenopodiaceae / Gangliosídeo G(M1) / Mucosa Intestinal Limite: Animals Idioma: En Revista: Cancer Lett Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Japão