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Effect of clinical doses of fluoxetine on psychological variables in healthy volunteers.
Gelfin, Y; Gorfine, M; Lerer, B.
Afiliação
  • Gelfin Y; Department of Psychiatry, Hadassah-Hebrew University Medical Center, Kiryat Hadassah-Ein Karem, Jerusalem, Israel.
Am J Psychiatry ; 155(2): 290-2, 1998 Feb.
Article em En | MEDLINE | ID: mdl-9464215
OBJECTIVE: The authors sought to determine the effect of clinically equivalent doses of fluoxetine on mood and other psychological variables in normal subjects. METHOD: Fifteen healthy volunteers received placebo for 2 weeks; fluoxetine, 10 mg/day, for 1 week; fluoxetine, 20 mg/day, for 5 weeks; and then an additional 2 weeks of placebo in the context of a single-blind study. The subjects were evaluated with a series of self- and observer-rated instruments. RESULTS: No significant effects attributable to fluoxetine were observed on any of the psychological variables examined. Minimal adverse effects were reported. CONCLUSIONS: Significant mood-elevating and other psychological effects of fluoxetine would appear to be induced only when symptomatic targets exist.
Assuntos
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Base de dados: MEDLINE Assunto principal: Satisfação Pessoal / Personalidade / Qualidade de Vida / Fluoxetina / Inibidores Seletivos de Recaptação de Serotonina / Afeto Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Psychiatry Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Israel
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Base de dados: MEDLINE Assunto principal: Satisfação Pessoal / Personalidade / Qualidade de Vida / Fluoxetina / Inibidores Seletivos de Recaptação de Serotonina / Afeto Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Psychiatry Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Israel