Effect of clinical doses of fluoxetine on psychological variables in healthy volunteers.
Am J Psychiatry
; 155(2): 290-2, 1998 Feb.
Article
em En
| MEDLINE
| ID: mdl-9464215
OBJECTIVE: The authors sought to determine the effect of clinically equivalent doses of fluoxetine on mood and other psychological variables in normal subjects. METHOD: Fifteen healthy volunteers received placebo for 2 weeks; fluoxetine, 10 mg/day, for 1 week; fluoxetine, 20 mg/day, for 5 weeks; and then an additional 2 weeks of placebo in the context of a single-blind study. The subjects were evaluated with a series of self- and observer-rated instruments. RESULTS: No significant effects attributable to fluoxetine were observed on any of the psychological variables examined. Minimal adverse effects were reported. CONCLUSIONS: Significant mood-elevating and other psychological effects of fluoxetine would appear to be induced only when symptomatic targets exist.
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Base de dados:
MEDLINE
Assunto principal:
Satisfação Pessoal
/
Personalidade
/
Qualidade de Vida
/
Fluoxetina
/
Inibidores Seletivos de Recaptação de Serotonina
/
Afeto
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Psychiatry
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Israel