Onset of hepatocellular carcinoma in a non-cirrhotic patient affected with haemochromatosis.
Oncol Rep
; 5(3): 723-5, 1998.
Article
em En
| MEDLINE
| ID: mdl-9538184
ABSTRACT
The increased incidence of hepatocellular carcinoma in patients affected with haemochromatosis has previously been attributed to cirrhosis. However, some cases of hepatocellular carcinoma without cirrhosis have recently been reported in patients with haemochromatosis, leading to reconsideration of the role of iron in the tumorigenesis of hepatocellular carcinoma. We describe a 79 year old male patient affected with haemochromatosis and with a multinodular hepatocellular carcinoma, but without any evidence of cirrhosis. The absence of any other cancer risk factor (alcohol abuse, liver viral infections, heredity) has lead us to reconsider the possible role of iron as a direct carcinogen in the onset of hepatocellular carcinoma in patients with haemochromatosis.
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma Hepatocelular
/
Hemocromatose
/
Neoplasias Hepáticas
Tipo de estudo:
Etiology_studies
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Oncol Rep
Assunto da revista:
NEOPLASIAS
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Itália