The intrinsic radiosensitivity of normal and tumour cells.
Int J Radiat Biol
; 73(4): 409-13, 1998 Apr.
Article
em En
| MEDLINE
| ID: mdl-9587079
ABSTRACT
PURPOSE:
To examine whether in vitro measurements of normal and tumour cell radiosensitivity can be used as prognostic factors in clinical oncology. MATERIALS ANDMETHODS:
Stage I-III cervix carcinoma patients were treated with radical radiotherapy with a minimum of 3 years' follow-up. Lymphocyte and tumour radiosensitivities were assayed using, respectively, a limiting dilution and soft agar clonogenic assay to obtain surviving fraction at 2 Gy (SF2). The results were related, in an actuarial analysis, to late morbidity assessed using the Franco Italian glossary.RESULTS:
Patients with radiosensitive lymphocytes had a significantly increased risk of developing late complications (n = 93, p = 0.002). Increasing tumour radiosensitivity was associated with an increased risk of morbidity (n= 113, p=0.032). A significant correlation was found between fibroblast and tumour cell radiosensitivity (r=0.57, p=0.03), but a weak inverse association was found between lymphocyte and tumour cell radiosensitivity (r= -0.32, p=0.03). Patients with radiosensitive lymphocytes and tumour cells had higher levels of late complications than those whose cells were radioresistant.CONCLUSION:
The work described highlights the importance of cellular radiosensitivity as a parameter determining the clinical response to radiotherapy.
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Base de dados:
MEDLINE
Assunto principal:
Tolerância a Radiação
/
Carcinoma
/
Linfócitos
/
Neoplasias do Colo do Útero
/
Fibroblastos
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Int J Radiat Biol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Reino Unido