Mice lacking the type I interleukin-1 receptor do not lose bone mass after ovariectomy.
Endocrinology
; 139(6): 3022-5, 1998 Jun.
Article
em En
| MEDLINE
| ID: mdl-9607815
ABSTRACT
We measured the effects of ovariectomy on the bone mass of mice that lacked type I interleukin-1 receptor (IL-I R1 -/- mice) in two genetic backgrounds (C57BL/6 x 129/Sv and C57BL/6) to investigate the role of interleukin-1 in the actions of estrogen on bone. At three weeks after surgery, ovariectomized wild-type mice decreased trabecular bone volume in the proximal humerus by 70% in a C57BL/6 x 129/Sv background and 48% in a C57BL/6 background compared to sham-operated controls. In contrast, there was no significant decrease in trabecular bone mass in IL-1 R1 -/- mice after ovariectomy. The estrogen status of all groups was confirmed by measurement of uterine wet weight. These results demonstrate that a functional IL-1 response pathway is required for mice to lose trabecular bone mass after ovariectomy in this model and they imply that IL-1 is an important mediator of the effects of ovariectomy on bone mass. Hence, therapeutic interventions that block the effects of IL-1 on bone may be beneficial for treating diseases of rapid bone loss such as post-menopausal osteoporosis.
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Base de dados:
MEDLINE
Assunto principal:
Ovariectomia
/
Densidade Óssea
/
Receptores de Interleucina-1
/
Camundongos Knockout
Limite:
Animals
Idioma:
En
Revista:
Endocrinology
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos