Fragile-X syndrome and myotonic dystrophy: parallels and paradoxes.
Curr Opin Genet Dev
; 8(2): 245-53, 1998 Apr.
Article
em En
| MEDLINE
| ID: mdl-9610417
ABSTRACT
Fragile-X syndrome and myotonic dystrophy are caused by triplet repeat expansions embedded in CpG islands in the transcribed non-coding regions of the FMR1 and the DMPK genes, respectively. Although initial reports emphasized differences in the mechanisms by which the expanded triplet repeats caused these diseases, results published in the past year highlight remarkable parallels in the likely molecular etiologies. At both loci, expansion is associated with altered chromatin, aberrant methylation, and suppressed expression of the adjacent FMR1 and DMAHP genes, implicating epigenetic mediation of these genetic diseases.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome do Cromossomo X Frágil
/
Distrofia Miotônica
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Genet Dev
Assunto da revista:
GENETICA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos