Lead poisoning, haem synthesis and 5-aminolaevulinic acid dehydratase.
Trends Biochem Sci
; 23(6): 217-21, 1998 Jun.
Article
em En
| MEDLINE
| ID: mdl-9644976
ABSTRACT
In mammals and yeast, 5-aminolaevulinic acid dehydratase is a zinc-dependent enzyme that catalyses the synthesis of porphobilinogen-the pyrrole building block that is incorporated into all modified tetrapyrroles, including haem, chlorophyll and vitamin B12. The X-ray structure of this enzyme reveals how substitution of the catalytically important zinc ion by lead inactivates the enzyme and causes a form of pseudo-porphyria.
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Base de dados:
MEDLINE
Assunto principal:
Sintase do Porfobilinogênio
/
Heme
/
Intoxicação por Chumbo
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Reino Unido