Combinatorial chemistry in insects: a library of defensive macrocyclic polyamines.
Science
; 281(5375): 428-31, 1998 Jul 17.
Article
em En
| MEDLINE
| ID: mdl-9665888
ABSTRACT
The pupal defensive secretion of the coccinellid beetle Epilachna borealis is composed principally of a combinatorial library of macrocyclic polyamines. These compounds constitute a previously unrecognized family of natural products, characterized by extremely large-ring lactonic structures derived from a small set of (2-hydroxyethylamino)alkanoic acids. The combinatorial assembly of these simple building blocks generates a high degree of structural diversity, which is further increased by slow, spontaneous intramolecular rearrangement of the macrocycles.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Poliaminas
/
Besouros
/
Aminoácidos
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos