Thrombopoietin: a potential T-helper lymphocyte stimulator. Change in T-lymphocyte composition and blood cytokine levels in thrombopoietin cDNA transferred mice.
Haematologica
; 83(6): 572-3, 1998 Jun.
Article
em En
| MEDLINE
| ID: mdl-9676034
The aim of this study was to evaluate the effect of thrombopoietin (TPO) on T lymphocyte in Balb/c mice delivered hTPO cDNA with plasmid vector. Both mature and immature T lymphocytes in central organs increased, but only the CD4+ subset was preferably proliferated in circulation. High serum IFN-gamma was coinciding with the declination of platelet counts, but TNF-alpha was positively associated with the platelet count, while high IL-2 level was similar to the course of TPO expression. Our data suggested that TPO is a stimulator for T lymphocytes, especially the CD4+ subset.
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Base de dados:
MEDLINE
Assunto principal:
Trombopoetina
/
Linfócitos T Auxiliares-Indutores
Limite:
Animals
Idioma:
En
Revista:
Haematologica
Ano de publicação:
1998
Tipo de documento:
Article