Tri-N-Boc-tetraazamacrocycle-nucleoside conjugates: synthesis and anti-HIV activities.
Nucleosides Nucleotides
; 17(5): 957-68, 1998 May.
Article
em En
| MEDLINE
| ID: mdl-9708333
ABSTRACT
As far as linear N-Boc-polyamines conjugates elicited remarkable anti-HIV activity, the synthesis and anti-HIV properties of cyclic N-Boc-polyamines conjugates such as tetraazamacrocycle-nucleoside were studied. These new conjugates include an ester linkage between the two moieties. They were synthesized using Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate coupling reagent, in the case of N-alkyl polyazamacrocycle derivatives, or through direct condensation of the acyl chloride derivative with nucleoside in the case of N-acyl polyazamacrocycle compounds. None of the new conjugates presented anti-HIV activity greater than that of the corresponding parent nucleosides.
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Base de dados:
MEDLINE
Assunto principal:
Poliaminas
/
Fármacos Anti-HIV
/
Nucleosídeos
Limite:
Humans
Idioma:
En
Revista:
Nucleosides Nucleotides
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
França