Side of seizure focus predicts left medial temporal lobe activation during verbal encoding.
Neurology
; 51(2): 479-84, 1998 Aug.
Article
em En
| MEDLINE
| ID: mdl-9710022
ABSTRACT
OBJECTIVE:
Functional MRI (FMRI) was used to investigate the effect of medial temporal lobe (MTL) pathology on activation of language encoding areas in patients with temporal lobe epilepsy (TLE).METHODS:
Whole-brain FMRI was obtained. Twenty-eight patients with either left TLE (LTLE) or right TLE (RTLE) performed a semantic decision task alternating with an auditory perceptual task.RESULTS:
Activation of language areas in the frontal and parietal lobes was similar in both groups, with no group differences in the total number of active voxels. However, the RTLE group showed much stronger activation of the left MTL, including the hippocampus, parahippocampal gyrus, and collateral sulcus, than did the LTLE group.CONCLUSIONS:
Activation of the left MTL during semantic encoding discriminates patients with RTLE and LTLE. This FMRI technique may potentially be of use in determining memory lateralization and for predicting the side of seizure focus in TLE.
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Base de dados:
MEDLINE
Assunto principal:
Lobo Temporal
/
Aprendizagem Verbal
/
Mapeamento Encefálico
/
Imageamento por Ressonância Magnética
/
Epilepsia do Lobo Temporal
/
Lateralidade Funcional
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurology
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos