Collagenous gastritis revealed by severe anemia in a child.
Hum Pathol
; 29(8): 883-6, 1998 Aug.
Article
em En
| MEDLINE
| ID: mdl-9712433
ABSTRACT
Collagenous gastritis is a rare histopathological disorder of unknown origin, characterized by a subepithelial collagen deposit greater than 10 microm thick, associated with an inflammatory infiltrate of the gastric mucosa. This report describes a second pediatric case of collagenous gastritis, revealed by severe anemia caused by gastric bleeding, as was the first case. Unlike the adult cases of collagenous gastritis, lesions were limited to the stomach, and remained unchanged on six series of biopsies taken during a 30 month follow-up, despite treatment with omeprazole, sucralfate and corticosteroids. An immunohistochemical study showed signs of local immune activation on all biopsy specimens, including overexpression of HLA-DR by epithelial cells, increased numbers of CD3+ intraepithelial lymphocytes, and CD25+ cells in the lamina propria. Although the cause of the disease remains unclear, our findings suggest that the histopathological lesions of collagenous gastritis may result from a local immune process.
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Base de dados:
MEDLINE
Assunto principal:
Colágeno
/
Doenças do Colágeno
/
Mucosa Gástrica
/
Gastrite
/
Anemia
Tipo de estudo:
Etiology_studies
Limite:
Child
/
Female
/
Humans
Idioma:
En
Revista:
Hum Pathol
Assunto da revista:
PATOLOGIA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
França