The cells and molecules that make a cerebellum.
Trends Neurosci
; 21(9): 375-82, 1998 Sep.
Article
em En
| MEDLINE
| ID: mdl-9735945
ABSTRACT
The molecular underpinnings of cerebellar development are being established through the identification of naturally occurring mutated genes and the knockout of other genes. Sets of genes expressed in the regions of the mes- and metencephalon have been shown to play a crucial role in specifying the cerebellar anlage. Other genes have been shown to be crucial to early granule-cell development, migration of Purkinje and granule cells, and neuron-glia interactions. However, the process of development will ultimately be understood in terms of cellular interactions and the roles that each cell type plays in the assembly of cerebellar structure. One of the most important interactions is between granule and Purkinje cells. This relationship has been shown to be crucial for the control of cell number, migration of neuroblasts and cell differentiation.
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Base de dados:
MEDLINE
Assunto principal:
Células de Purkinje
/
Movimento Celular
/
Cerebelo
Limite:
Animals
Idioma:
En
Revista:
Trends Neurosci
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos