Apoptosis-gene expression in hematopoietic system: normal and pathological conditions (Review).
Int J Mol Med
; 1(1): 121-9, 1998 Jan.
Article
em En
| MEDLINE
| ID: mdl-9852209
ABSTRACT
Gene expression involving apoptosis in the hematopoietic system is reviewed. In normal and hematological disorders, Fas-Fas ligand and tumor necrosis factor-alpha-receptor interaction play a major role in enhancing apoptosis. On the other hand, bcl-2 or certain novel proteins (including FADD, RIP, TRADD and sentrin) prevent apoptosis. Apoptosis is involved in myelodysplastic syndrome and pathogenesis of leukemia. Expression of Fas antigen plays a role in negative regulation of hematopoiesis in the bone marrow as does interferon-gamma.
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Base de dados:
MEDLINE
Assunto principal:
Expressão Gênica
/
Apoptose
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Mol Med
Assunto da revista:
BIOLOGIA MOLECULAR
/
GENETICA MEDICA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Japão