Anticomplementary activity of stilbenes from medicinal plants.
Arch Pharm Res
; 21(6): 703-6, 1998 Dec.
Article
em En
| MEDLINE
| ID: mdl-9868541
ABSTRACT
The anticomplementary activity of stilbenes from medicinal plants in Korea was investigated in vitro. 3,5-Dihydroxy-4'-methoxystilbene (3) was most potent with IC50 value of 1.5 x 10(-4) M followed by rhapontigenin (4), oxyresverastrol (2), 2,3,4',5-tetrahydroxystilbene-2-O-beta-glucoside (9), rhaponticin (8), resverastrol (1), and piceid (7). The activity was found to be increased by a methylation on a hydroxy group of C-4' of 1, but decreased by further methylation on hydroxy groups of C-3 and C-5 and glucosylation on any hydroxy group of 1. Addition of hydroxy group on C-2' of 1 or C-3' of 3 was little affected on the anticomplementary activity but the activity was increased by O-glucosylation on C-2 of 1.
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Base de dados:
MEDLINE
Assunto principal:
Estilbenos
/
Proteínas Inativadoras do Complemento
Idioma:
En
Revista:
Arch Pharm Res
Ano de publicação:
1998
Tipo de documento:
Article