The inhibitory effects of the fluoroquinolone antimicrobials norfloxacin and enrofloxacin on hepatic microsomal cytochrome P-450 monooxygenases in broiler chickens.

Shlosberg, A; Ershov, E; Bellaiche, M; Hanji, V; Weisman, Y; Soback, S

Shlosberg, A; Ershov, E; Bellaiche, M; Hanji, V; Weisman, Y; Soback, S.

Afiliação

Shlosberg A; Kimron Veterinary Institute, Bet Dagan, Israel.

Drug Metabol Drug Interact ; 14(2): 109-22, 1997.

Article em En | MEDLINE | ID: mdl-9893741

ABSTRACT

ABSTRACT

The fluoroquinolone antimicrobials norfloxacin and enrofloxacin were found to inhibit hepatic microsomal cytochrome P-450 monooxygenases in the livers of broiler chickens using dosages as given in commercial flocks. Norfloxacin inhibited the process of N-demethylation of aminopyrine to a greater degree, while enrofloxacin more markedly inhibited hydroxylation of aniline.

Assuntos

Anti-Infecciosos/farmacologia; Galinhas/metabolismo; Inibidores das Enzimas do Citocromo P-450; Fluoroquinolonas; Norfloxacino/farmacologia; Quinolonas/farmacologia; Aminopirina N-Desmetilase/efeitos dos fármacos; Aminopirina N-Desmetilase/metabolismo; Anilina Hidroxilase/efeitos dos fármacos; Anilina Hidroxilase/metabolismo; Animais; Enrofloxacina; Fígado/anatomia & histologia; Masculino; Microssomos Hepáticos/enzimologia; Tamanho do Órgão/efeitos dos fármacos

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Base de dados: MEDLINE Assunto principal: Norfloxacino / Galinhas / Quinolonas / Fluoroquinolonas / Inibidores das Enzimas do Citocromo P-450 / Anti-Infecciosos Limite: Animals Idioma: En Revista: Drug Metabol Drug Interact Assunto da revista: FARMACOLOGIA Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Israel

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