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Introduction: Data on burden and treatment outcomes of chronic spontaneous urticaria (CSU) in Russia are limited. Poor adherence to recommended treatments can lead to suboptimal management of CSU patients. Aim: To understand disease burden, treatment algorithms, and outcomes of CSU in the Russian cohort of the AWARE study. Material and methods: AWARE was a global prospective, non-interventional study of chronic urticaria in the real-world setting. Adult patients with H1-antihistamines (H1AH)-refractory CSU for ≥ 2 months were included. Disease characteristics, quality of life (QoL), healthcare resource utilisation (HRU), and pharmacological treatments were observed during the 2-year study period. Results: Of the 135 patients enrolled from Russia, 121 completed the study. Pre-baseline, ~37% of patients were managed with non-recommended treatments (33% treated with sedative H1AH; 4% with other non-recommended treatments) and 28.2% of patients were not treated for CSU. There was a reduction in the use of sedative H1AH during the study (0.9% of patients treated with sedative H1AHs at Year 2). Decreased disease activity was seen as early as 3 months and continued to improve over 2 years (Urticaria Activity Score over 7 days (UAS7): 20.2 at baseline (n = 124) to 10.1, 7.1, and 3.2 at month 3 (n = 118), 12 (n = 109), and 24 (n = 109), respectively). This corresponded with QoL improvements (dermatology life quality index (DLQI) score: 10.3 at baseline to 5.4, 3.6, and 2.3 at Month 3 (n = 75), 12 (n = 98), and 24 (n = 92), respectively), and reduced angioedema and hives throughout the study. Conclusions: The burden of CSU in Russia is high, contributing to increased HRU. Guideline-recommended treatments and systematic escalation of therapy to achieve complete symptom control can improve management of patients with CSU.
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BACKGROUND: Inflammatory diseases of the pelvic organs, associated also with conditionally pathogenic flora, play a key role in the development of several pathological changes in the organs of the urogenital tract in women, including tumors, infertility, etc. Objective is to determine the role of conditionally pathogenic sexually transmitted infections in the formation of pathological conditions of the cervix in women of reproductive age. METHODS: One hundred fifty-one patients aged 20-35 year participated in this cross-sectional study. These patients were examined with the use of a complex of clinical, laboratory and instrumental methods of examination. These women underwent a specific treatment. The next treatment regimen was administered: josamycin 500 mg orally 3 times a day for 10 days or doxycycline monohydrate 100 mg orally 2 times a day after a meal for 10 days. RESULTS: Conditionally pathogenic sexually transmitted infection is widespread among women of reproductive age, accounting for 46.0%. In 88.7% of cases, the clinical manifestations are subjectively asymptomatic, i.e., the patient did not have any complaints, but 86.15% of them have various lesions of the cervix and cervical canal. Moreover, under the influence of opportunistic sexually transmitted infections, basic functional parameters of cervical mucus get worse significantly. This greatly reduces the quality of the reproductive function in these patients. CONCLUSIONS: Providing proper diagnostic procedures and adequate and rational treatment of inflammatory diseases is a condition to prevent the development of pathological conditions of the cervix and cervical canal.