1.
Cell Immunol
; 292(1-2): 85-93, 2014.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25460083
RESUMO
We established a novel model of myocarditis induced with Theiler's murine encephalomyelitis virus (TMEV), which has been used as a viral model for multiple sclerosis and seizure/epilepsy. Following TMEV infection, C3H mice developed severe myocarditis with T cell infiltration, while C57BL/6 mice had mild lesions and SJL/J mice had no inflammation in the heart. In C3H mice, myocarditis was divided into three phases: acute viral, subacute immune, and chronic fibrotic phases. Using toll-like receptor (TLR) 4-deficient C3H mice, we found that interleukin (IL)-6, IL-17, TLR4, and anti-viral immune responses were associated with myocarditis susceptibility.
Assuntos
Miocardite/imunologia , Linfócitos T/imunologia , Theilovirus/fisiologia , Replicação Viral , Animais , Fibrose/imunologia , Cinética , Camundongos Endogâmicos , Miocardite/patologia , Miocardite/virologia
2.
Int J Cardiol
; 176(2): 484-5, 2014 Sep 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25127978