Detalhe da pesquisa
1.
A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species.
Mol Microbiol
; 106(3): 439-451, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28836704
2.
Crystal structure of lipoate-bound lipoate ligase 1, LipL1, from Plasmodium falciparum.
Proteins
; 85(9): 1777-1783, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28543853
3.
Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum.
Mol Microbiol
; 94(1): 156-71, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25116855
4.
The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target.
Bioorg Med Chem Lett
; 24(3): 911-6, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24398298
5.
Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay.
Biochemistry
; 52(51): 9155-66, 2013 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24295325
6.
Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides.
Bioorg Med Chem Lett
; 23(12): 3551-5, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23664871
7.
Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase.
Bioorg Med Chem Lett
; 23(7): 2035-43, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23453069
8.
Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway.
Antimicrob Agents Chemother
; 56(5): 2666-82, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22354304
9.
Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.
ACS Infect Dis
; 5(1): 90-101, 2019 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30375858
10.
Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs.
Structure
; 26(11): 1499-1512.e5, 2018 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30197036
11.
Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agents.
ChemMedChem
; 8(3): 442-61, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23341167
12.
Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii.
ChemMedChem
; 8(7): 1138-60, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23776166