Detalhe da pesquisa
1.
Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.
Bioorg Med Chem
; 28(1): 115232, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31818630
2.
Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache.
Bioorg Med Chem Lett
; 27(2): 323-328, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27908761
3.
Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator.
J Med Chem
; 67(7): 5259-5271, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38530741
4.
RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease.
J Allergy Clin Immunol
; 137(3): 960-3, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26611672
5.
Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ) Agonist for Use in Treating Cancer.
J Med Chem
; 64(18): 13410-13428, 2021 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34499493
6.
Novel acyl coenzyme A (CoA): diacylglycerol acyltransferase-1 inhibitors: synthesis and biological activities of diacylethylenediamine derivatives.
Bioorg Med Chem
; 18(7): 2785-95, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20207151
7.
Non-charged thiamine analogs as inhibitors of enzyme transketolase.
Bioorg Med Chem Lett
; 18(2): 509-12, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18182286
8.
Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394.
ACS Med Chem Lett
; 7(7): 714-8, 2016 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27437083
9.
Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity.
Oncoimmunology
; 5(12): e1254854, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-28123897
10.
Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity.
Cell Rep
; 17(12): 3206-3218, 2016 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28009290
11.
Perhydroquinolylbenzamides as novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
J Med Chem
; 48(21): 6696-712, 2005 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16220986
12.
Discovery of 2-pyridylureas as glucokinase activators.
J Med Chem
; 57(19): 8180-6, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25203462
13.
C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators.
ACS Med Chem Lett
; 5(12): 1284-9, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25516785
14.
Identification of a new class of glucokinase activators through structure-based design.
J Med Chem
; 56(19): 7669-78, 2013 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24015910
15.
A novel coenzyme A:diacylglycerol acyltransferase 1 inhibitor stimulates lipid metabolism in muscle and lowers weight in animal models of obesity.
Eur J Pharmacol
; 650(2-3): 663-72, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21034741
16.
Novel therapeutics and targets for the treatment of diabetes.
Expert Rev Clin Pharmacol
; 3(2): 209-29, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22111568