Detalhe da pesquisa
1.
G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions.
J Biol Chem
; 299(10): 105218, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37660910
2.
G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin.
J Biol Chem
; 298(10): 102421, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36030052
3.
Functional characterization of a PROTAC directed against BRAF mutant V600E.
Nat Chem Biol
; 16(11): 1170-1178, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32778845
4.
A drug discovery platform to identify compounds that inhibit EGFR triple mutants.
Nat Chem Biol
; 16(5): 577-586, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32094923
5.
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.
Nature
; 525(7568): 206-11, 2015 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26331536
6.
Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport.
J Biol Chem
; 294(12): 4546-4571, 2019 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30696771
7.
Antagonists of the serotonin receptor 5A target human breast tumor initiating cells.
BMC Cancer
; 20(1): 724, 2020 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32758183
8.
Discovery of an MLLT1/3 YEATS Domain Chemical Probe.
Angew Chem Int Ed Engl
; 57(50): 16302-16307, 2018 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30288907
9.
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
Nat Chem Biol
; 11(8): 571-578, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26167872
10.
Small molecules reveal an alternative mechanism of Bax activation.
Biochem J
; 473(8): 1073-83, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26916338
11.
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
Proc Natl Acad Sci U S A
; 111(35): 12853-8, 2014 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25136132
12.
PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma.
J Transl Med
; 14: 67, 2016 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26952093
13.
Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells.
Apoptosis
; 20(7): 948-59, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25832785
14.
A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside.
Blood
; 119(5): 1200-7, 2012 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22160482
15.
Use of kinase inhibitors to correct ΔF508-CFTR function.
Mol Cell Proteomics
; 11(9): 745-57, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22700489
16.
Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
Biochem J
; 449(1): 151-9, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22989411
17.
Discovery of Conformationally Constrained ALK2 Inhibitors.
J Med Chem
; 67(6): 4707-4725, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38498998
18.
The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia.
Cancer Res
; 84(7): 1084-1100, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38266099
19.
Rearrangement of 4-amino-3-halo-pyridines by nucleophilic aromatic substitution.
J Org Chem
; 78(11): 5705-10, 2013 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23700973
20.
Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.
Bioorg Med Chem
; 21(7): 1787-1794, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23433670