Detalhe da pesquisa
1.
Nonclinical safety evaluation of a novel ionizable lipid for mRNA delivery.
Toxicol Appl Pharmacol
; 451: 116143, 2022 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35843341
2.
Predicting DNA-Reactivity of N-Nitrosamines: A Quantum Chemical Approach.
Chem Res Toxicol
; 35(11): 2068-2084, 2022 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36302168
3.
Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: is aromatic N-oxide a structural alert for predicting DNA-reactive mutagenicity?
Mutagenesis
; 34(1): 67-82, 2019 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30189015
4.
Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites.
J Biochem Mol Toxicol
; 33(8): e22345, 2019 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-31066974
5.
Principles and procedures for handling out-of-domain and indeterminate results as part of ICH M7 recommended (Q)SAR analyses.
Regul Toxicol Pharmacol
; 102: 53-64, 2019 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-30562600
6.
Genetic toxicology in silico protocol.
Regul Toxicol Pharmacol
; 107: 104403, 2019 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-31195068
7.
In silico toxicology protocols.
Regul Toxicol Pharmacol
; 96: 1-17, 2018 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-29678766
8.
Computational Models for Human and Animal Hepatotoxicity with a Global Application Scope.
Chem Res Toxicol
; 29(5): 757-67, 2016 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26914516
9.
It's difficult, but important, to make negative predictions.
Regul Toxicol Pharmacol
; 76: 79-86, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26785392
10.
Evaluation of a statistics-based Ames mutagenicity QSAR model and interpretation of the results obtained.
Regul Toxicol Pharmacol
; 76: 7-20, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26708083
11.
Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity.
Regul Toxicol Pharmacol
; 77: 1-12, 2016 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26879463
12.
Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses.
Regul Toxicol Pharmacol
; 77: 13-24, 2016 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26877192
13.
Establishing best practise in the application of expert review of mutagenicity under ICH M7.
Regul Toxicol Pharmacol
; 73(1): 367-77, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26248005
14.
Toward implementing virtual control groups in nonclinical safety studies.
ALTEX
; 41(2): 282-301, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38043132
15.
Use of in silico systems and expert knowledge for structure-based assessment of potentially mutagenic impurities.
Regul Toxicol Pharmacol
; 67(1): 39-52, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23669331
16.
In silico approaches in carcinogenicity hazard assessment: case study of pregabalin, a nongenotoxic mouse carcinogen.
Front Toxicol
; 5: 1234498, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38026843
17.
Intra- and interlaboratory reproducibility of ultra performance liquid chromatography-time-of-flight mass spectrometry for urinary metabolic profiling.
Anal Chem
; 84(5): 2424-32, 2012 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22304021
18.
Principles and Procedures for Assessment of Acute Toxicity Incorporating In Silico Methods.
Comput Toxicol
; 242022 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-36818760
19.
EU framework 6 project: predictive toxicology (PredTox)--overview and outcome.
Toxicol Appl Pharmacol
; 252(2): 73-84, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20955723
20.
A comparative integrated transcript analysis and functional characterization of differential mechanisms for induction of liver hypertrophy in the rat.
Toxicol Appl Pharmacol
; 252(2): 85-96, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21315101