[Eicosanoids in septic shock in rats]. / Eikosanoidi u septickom soku kod pacova.

In order to evaluate the role of eicosanoids in pathogenesis of septic shock, the dynamics of TxA2, PGE2 and peptidoleukotriene contents has been measured in the liver of rats with surgically induced septic shock (sesum resection). In the same time the general parameters have been followed up: survival, body temperature, hematocrit and glucose contents in the plasma of experimental animals. Aiming to differentiate the importance of some eicosanoids, immediately after surgery methyl prednisolone (phospholipase A2 inhibitor) or indomethacin (cyclooxigenase enzyme inhibitor) have been given. Based on own results the authors have concluded that in pathogenetic mechanisms of septic shock the main role have peptidoleukotrienes, lipooxygenase products of degradation of arachidonic acid.

[Metabolic changes as part of the general response of the body to the effect of blast waves]. / Metabolicke promene kao sastavni deo opste reakcije organizma na delovanje udarnog talasa.

Aiming to understand general response of the body to effects of blast wave there have been examined products of carbo-hydrates metabolism (glycogen, glucose, pyruvate, malate, oxalacetate) and of energy metabolism (ATP, ADP, AMP, inorganic phosphorus, energy state, potential of phosphorylation) in tissues of the liver and heart of sheep exposed to blast wave generated by detonation of the aerosol explosive. The authors have concluded that changes in the metabolism of carbo-hydrates and energy occurred in the tissue of the liver and heart after effects of blast wave are nonspecific and that they developed in the scope of general response of the body to trauma. It is possible that lung damages, as a local reaction to blast wave modify/modulate (aggrevate) the found changes.

[Changes in serum enzyme values as possible indicators of the severity of blast injuries]. / Promene vrednosti enzima u serumu kao moguci pokazatelj tezine blast povrede.

In order to detect biochemical parameters in the peripheral blood which would serve as an indicator of severity of blast injuries, the enzyme dynamics (creatine kinase, aspartat transaminase, alanin transaminase, lactic dehydrogenase, alkaline phosphatase, angiotensin convertase) has been followed up in the serum of sheep. The significant increase was found in the values of creatine kinase, aspartat transaminase and alanine transaminase in the serum of the experimental animals an hour after effects of the blast wave. The authors have concluded that changes of the mentioned enzymes can serve as one of signs of damages of the lungs and gastrointestinal tract caused by blast wave in the early posttraumatic period.

[Pathophysiologic reactions in sheep to blast waves from detonation of aerosol explosives]. / Patofizioloske reakcije kod ovaca na udarni talas nastao detonacijom aerosolnog eksploziva.

In the controlled field experiments 18 sheep were exposed to the detonation of the aerosol explosive generating the blast wave necessary to produce death in 50% of cases. The time of death and characteristic damages on the predilection sites of some organs are interpreted as blast type injuries. General response of the body to blast wave was similar to the one produced by other etiological factors. A special characteristic of the experiment was the frequency and severity of pathologic changes on the internal organs of the chest and abdomen. According to the authors' opinion the severity and type of pathologic changes could be explained by effects of the complex blast wave generated by detonation of the aerosol explosives.