Detalhe da pesquisa
1.
Common activities and predictive gene signature identified for genetic hypomorphs of TP53.
Proc Natl Acad Sci U S A
; 120(7): e2212940120, 2023 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36749725
2.
Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α.
Genes Dev
; 32(3-4): 230-243, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29463573
3.
Ras signaling through RASSF proteins.
Semin Cell Dev Biol
; 58: 86-95, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27288568
4.
Ras Regulates Rb via NORE1A.
J Biol Chem
; 291(6): 3114-23, 2016 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26677227
5.
Mechanistic insights into medulloblastoma relapse.
Pharmacol Ther
; : 108673, 2024 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38857789
6.
HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer.
Cell Death Differ
; 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38802657
7.
Triptolide and its pro-drug Minnelide target high-risk MYC amplified medulloblastoma in preclinical models.
J Clin Invest
; 2024 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38885332
8.
PRIMA-1 inhibits Y220C p53 amyloid aggregation and synergizes with cisplatin in hepatocellular carcinoma.
Front Mol Biosci
; 10: 1165132, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37101558
9.
The African-centric P47S Variant of TP53 Confers Immune Dysregulation and Impaired Response to Immune Checkpoint Inhibition.
Cancer Res Commun
; 3(7): 1200-1211, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37441266
10.
An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.
Cancer Discov
; 13(7): 1696-1719, 2023 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37140445
11.
Shifting the paradigms for tumor suppression: lessons from the p53 field.
Oncogene
; 40(25): 4281-4290, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34103683
12.
HSP70 inhibition blocks adaptive resistance and synergizes with MEK inhibition for the treatment of NRAS-mutant melanoma.
Cancer Res Commun
; 1(1): 17-29, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35187538
13.
Author Correction: African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin.
Nat Commun
; 11(1): 1541, 2020 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32193389
14.
African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin.
Nat Commun
; 11(1): 473, 2020 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31980600
15.
Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser.
Elife
; 92020 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33170774
16.
A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors.
Cancer Res
; 80(23): 5270-5281, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33023943
17.
A Rare TP53 Mutation Predominant in Ashkenazi Jews Confers Risk of Multiple Cancers.
Cancer Res
; 80(17): 3732-3744, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32675277
18.
Tumor cells containing the African-Centric S47 variant of TP53 show increased Warburg metabolism.
Oncotarget
; 10(11): 1217-1223, 2019 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30838093
19.
Common genetic variants in the TP53 pathway and their impact on cancer.
J Mol Cell Biol
; 11(7): 578-585, 2019 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31152665
20.
The transcription-independent mitochondrial cell death pathway is defective in non-transformed cells containing the Pro47Ser variant of p53.
Cancer Biol Ther
; 19(11): 1033-1038, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30010463