Detalhe da pesquisa
1.
The genetic architecture of type 2 diabetes.
Nature
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Artigo
em Inglês
| MEDLINE | ID: mdl-27398621
2.
Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling.
Development
; 145(16)2018 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30042179
3.
Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits.
PLoS Comput Biol
; 16(8): e1008044, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32797044
4.
Patterns of differential gene expression in a cellular model of human islet development, and relationship to type 2 diabetes predisposition.
Diabetologia
; 61(7): 1614-1622, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29675560
5.
Diverse type 2 diabetes genetic risk factors functionally converge in a phenotype-focused gene network.
PLoS Comput Biol
; 13(10): e1005816, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-29059180
6.
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
PLoS Genet
; 11(1): e1004876, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25625282
7.
Discovery of a novel site regulating glucokinase activity following characterization of a new mutation causing hyperinsulinemic hypoglycemia in humans.
J Biol Chem
; 286(21): 19118-26, 2011 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21454522
8.
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.
Hum Mol Genet
; 18(21): 4081-8, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19643913
9.
Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure.
iScience
; 24(6): 102552, 2021 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34151225
10.
Analysis of Differentiation Protocols Defines a Common Pancreatic Progenitor Molecular Signature and Guides Refinement of Endocrine Differentiation.
Stem Cell Reports
; 14(1): 138-153, 2020 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31883919
11.
Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.
Hum Mutat
; 30(11): 1512-26, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19790256
12.
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.
Nat Genet
; 51(11): 1596-1606, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31676859
13.
Derivation and molecular characterization of pancreatic differentiated MODY1-iPSCs.
Stem Cell Res
; 31: 16-26, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29990710
14.
Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic ß-cells.
Nat Genet
; 50(8): 1122-1131, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30054598
15.
NKX6.1 induced pluripotent stem cell reporter lines for isolation and analysis of functionally relevant neuronal and pancreas populations.
Stem Cell Res
; 29: 220-231, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29734117
16.
Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
Sci Data
; 5: 180002, 2018 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29360107
17.
Genes Associated with Pancreas Development and Function Maintain Open Chromatin in iPSCs Generated from Human Pancreatic Beta Cells.
Stem Cell Reports
; 9(5): 1395-1405, 2017 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29107594
18.
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
Sci Data
; 4: 170179, 2017 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29257133
19.
Genome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biology.
F1000Res
; 52016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27508066
20.
Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model.
Islets
; 8(3): 83-95, 2016 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27246810