Autoimmune Hepatitis and Obstetrical Outcomes: A Nationwide Assessment.

INTRODUCTION: Previous research identified AIH as linked to unfavorable obstetrical outcomes in a US nationwide retrospective study from 2012-2016. Our aim is to update the literature and strengthen the AIH-pregnancy outcomes relationship. METHODS: Using the National Inpatient Sample database in the US, from 2016 to 2020, we compared pregnant females with a diagnosis of AIH to those with and without other chronic liver diseases (CLD), using ICD-10-CM codes. Baseline characteristics were analyzed using T-test and Chi-Square, and multivariate regression was used to estimate the differences in maternal outcomes adjusted for age, race, insurance status, geographical location, hospital characteristics, and comorbid conditions. RESULTS: Out of 19,392,328 hospitalizations for pregnant females ≥ 18 years old from 2016 to 2020, 1095 had AIH, 179,655 had CLD, and 19,206,696 had no CLD. No mortality was observed among individuals with AIH. When compared to individuals without CLD, AIH was associated with an 82% increase in the odds of preterm delivery (AIH: 8% vs. Without CLD: 5%, adjusted Odds Ratio = 1.82, 95% CI 1.06-3.14), with no significant differences in gestational diabetes mellitus, hypertensive complications, and postpartum hemorrhage, and a 0.6 day longer hospital stay. Furthermore, there were no significant differences in outcomes between AIH and CLD. CONCLUSIONS: Our study reinforces the association of AIH with adverse obstetrical outcomes (e.g., preterm delivery), however, we found that there is no difference in GDM and hypertensive complications, as suggested in prior studies. Therefore, further investigations are needed to clarify the association between AIH and these obstetrical complications.

Post-Traumatic Growth Among Frontline Doctors Fighting Against COVID-19 At A Tertiary Care Public Hospital In Karachi, Pakistan.

Objective: To evaluate post-traumatic growth experienced by medical doctors who served coronavirus disease 2019 patients. METHODS: The cross-sectional study was conducted from December 1, 2021, to February 28, 2022, at the Civil Hospital, Karachi, and comprised medical doctors of either gender aged >22 years who directly provided care for at least one month to coronavirus disease-2019 patients. Other than demographic and professional profile of the subjects, data was collected using the Post-Traumatic Growth Inventory, with total score ≥60 indicating a positive post-traumatic growth. Data was analysed using SPSS 22. RESULTS: Of the 166 subjects approached, 150(90.3%) finished the study. There were 90(60%) females, 88(58.7%) were aged 25-35 years, 55(36.7%) were married, 107(71.3%) were postgraduate trainees, 79(52.7%) had 1-3 family members in the vulnerable groups, and 43(28.7%) had received any sort of psychological training. The mean post traumatic growth score was 64.81±20.27 and 87(58%) doctors scored ≥60. The odds of experiencing post- traumatic growth for doctors with the number of vulnerable family members were significant (p<0.05). Doctors who had received psychological training before providing care to coronavirus disease-2019 patients showed higher odds of experiencing post-traumatic growth (p<0.05). Conclusion: Coronavirus disease-2019 resulted in substantial positive psychological growth for frontline doctors. Psychological training showed a significant role in post-traumatic growth.