RESUMO
We describe here the United Kingdom (UK) response following the recent international recall of an organ preservation fluid owing to potential Bacillus cereus contamination. This fluid is used for the transport of solid organs and pancreatic islet cells for transplant. We detail the response mechanisms, including the initial risk stratification, investigatory approaches, isolate analysis and communications to professional bodies. This report further lays out the potential need for enhanced surveillance in UK transplant patients.
Assuntos
Bacillus cereus , Contaminação de Medicamentos , Soluções para Preservação de Órgãos , Infecções por Bacillaceae/epidemiologia , Infecções por Bacillaceae/microbiologia , Bacillus cereus/isolamento & purificação , Qualidade de Produtos para o Consumidor , Eletroforese em Gel de Campo Pulsado , Humanos , Reino UnidoRESUMO
An inflammatory exudate collected from a site of major surgery (partial gastrectomy) was found to possess definite anti-inflammatory properties when tested by the carrageenin oedema technique (a method widely adopted for the assessment of potential anti-rheumatic agents). Such anti-inflammatory properties could not be detected in the serum of normal healthy adults or in an abdominal asdtes fluid. The active component in the exudate showed several properties in common with a similar anti-inflammatory substance present in inflammatory exudates of animal origin.