EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy.

Food allergy can result in considerable morbidity, impairment of quality of life, and healthcare expenditure. There is therefore interest in novel strategies for its treatment, particularly food allergen immunotherapy (FA-AIT) through the oral (OIT), sublingual (SLIT), or epicutaneous (EPIT) routes. This Guideline, prepared by the European Academy of Allergy and Clinical Immunology (EAACI) Task Force on Allergen Immunotherapy for IgE-mediated Food Allergy, aims to provide evidence-based recommendations for active treatment of IgE-mediated food allergy with FA-AIT. Immunotherapy relies on the delivery of gradually increasing doses of specific allergen to increase the threshold of reaction while on therapy (also known as desensitization) and ultimately to achieve post-discontinuation effectiveness (also known as tolerance or sustained unresponsiveness). Oral FA-AIT has most frequently been assessed: here, the allergen is either immediately swallowed (OIT) or held under the tongue for a period of time (SLIT). Overall, trials have found substantial benefit for patients undergoing either OIT or SLIT with respect to efficacy during treatment, particularly for cow's milk, hen's egg, and peanut allergies. A benefit post-discontinuation is also suggested, but not confirmed. Adverse events during FA-AIT have been frequently reported, but few subjects discontinue FA-AIT as a result of these. Taking into account the current evidence, FA-AIT should only be performed in research centers or in clinical centers with an extensive experience in FA-AIT. Patients and their families should be provided with information about the use of FA-AIT for IgE-mediated food allergy to allow them to make an informed decision about the therapy.

The past conditional verb form in French children: the role of semantics in late grammatical development.

As shown by Bowerman (1986), it has proved remarkably difficult to find clear-cut interpretations of why children face problems with conditionals. The present study reassesses a part of this puzzle by analysing four- to eight-year-old French children's acquisition of conditional verb forms. Relevant data in the literature and results of an experiment designed to gain information on the temporal meaning of young children's past conditional verb forms are presented and discussed. Among others, they are shown to provide weak support for interpretations stressing the role of conceptual problems and related mapping problems. Meeting one of Slobin's (1985) proposals, an interpretation is suggested that views the lateness of the past conditional verb form as due to an unexpected juxtaposition of 'possibility' and 'non-possibility' in its semantic representation. It is argued that such a juxtaposition cannot be achieved on the sole basis of cognitive development and that it requires the preliminary mastery of the conditional verb form.