Detalhe da pesquisa
1.
Evaluation of 2'-α-fluorine modified nucleoside phosphonates as potential inhibitors of HCV polymerase.
Bioorg Med Chem Lett
; 23(11): 3354-7, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23639543
2.
Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148.
Bioorg Med Chem
; 18(10): 3606-17, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20409721
3.
Design, synthesis, and anti-HIV activity of 4'-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors.
Bioorg Med Chem
; 17(4): 1739-46, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19179082
4.
Synthesis and anti-HIV activity of GS-9148 (2'-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor.
Bioorg Med Chem Lett
; 18(3): 1120-3, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18164198
5.
Synthesis and anti-HIV activity of 2'-fluorine modified nucleoside phosphonates: analogs of GS-9148.
Bioorg Med Chem Lett
; 18(3): 1116-9, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18082402
6.
Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates.
Bioorg Med Chem Lett
; 17(24): 6785-9, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18029175
7.
Synthesis and anti-HIV activity of cyclic pyrimidine phosphonomethoxy nucleosides and their prodrugs: a comparison of phosphonates and corresponding nucleosides.
Nucleosides Nucleotides Nucleic Acids
; 26(6-7): 573-7, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-18066858
8.
Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex.
J Mol Biol
; 397(4): 967-78, 2010 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-20156454
9.
Synthesis of beta-C-Glycosides of N-Acetylglucosamine via Keck Allylation Directed by Neighboring Phthalimide Groups.
J Org Chem
; 61(18): 6442-6445, 1996 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-11667491
10.
Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent.
Antimicrob Agents Chemother
; 52(2): 648-54, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18056281
11.
Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.
Antimicrob Agents Chemother
; 52(2): 655-65, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18056282
12.
Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs.
Bioorg Med Chem
; 15(16): 5519-28, 2007 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17562366
13.
Synthetic dihydropacidamycin antibiotics: a modified spectrum of activity for the pacidamycin class.
Bioorg Med Chem Lett
; 13(19): 3305-9, 2003 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12951115