Detalhe da pesquisa
1.
Our Exciting Journey to ACT-451840.
Chimia (Aarau)
; 75(11): 916-922, 2021 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34798913
2.
20 Years of Medicinal Chemistry - Always Look at the Bright Side (of Life).
Chimia (Aarau)
; 74(7): 549-560, 2020 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32778207
3.
The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468.
J Pharmacol Exp Ther
; 362(3): 489-503, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28663311
4.
The Screening Compound Collection: A Key Asset for Drug Discovery.
Chimia (Aarau)
; 71(10): 667-677, 2017 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29070412
5.
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.
PLoS Med
; 13(10): e1002138, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27701420
6.
From bosentan (Tracleer®) to macitentan (Opsumit®): The medicinal chemistry perspective.
Bioorg Med Chem Lett
; 26(15): 3381-94, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27321813
7.
Recent trends in orexin research--2010 to 2015.
Bioorg Med Chem Lett
; 25(15): 2875-87, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26045032
8.
Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2.
Bioorg Med Chem Lett
; 25(9): 1884-91, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25838147
9.
UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells.
J Biol Chem
; 288(31): 22576-83, 2013 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23754276
10.
Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure-activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1.
Bioorg Med Chem Lett
; 24(4): 1201-8, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24447850
11.
Design of Dual EP2/EP4 Antagonists through Scaffold Merging of Selective Inhibitors.
ChemMedChem
; 19(2): e202300606, 2024 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37983645
12.
Discovery of Nivasorexant (ACT-539313): The First Selective Orexin-1 Receptor Antagonist (SO1RA) Investigated in Clinical Trials.
J Med Chem
; 67(4): 2337-2348, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38331429
13.
Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure-activity-relationship, and sleep-promoting properties in rats.
RSC Med Chem
; 15(1): 344-354, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38283232
14.
Synthesis, structure-activity relationship studies, and identification of novel 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 1.
Bioorg Med Chem Lett
; 23(7): 2212-6, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23434414
15.
Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffold.
Bioorg Med Chem Lett
; 23(3): 658-62, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23260352
16.
Structure-activity relationship studies and sleep-promoting activity of novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 2.
Bioorg Med Chem Lett
; 23(13): 3857-63, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23719231
17.
Identification of a new chemical class of antimalarials.
J Infect Dis
; 206(5): 735-43, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22732921
18.
Design, Synthesis, and Optimization of Indole Acetic Acid Derivatives as Potent and Selective CRTH2 Receptor Antagonists: Discovery of ACT-774312.
ChemMedChem
; 18(10): e202300007, 2023 05 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36888561
19.
CYP3A4 Catalyzes the Rearrangement of the Dual Orexin Receptor Antagonist Daridorexant to 4-Hydroxypiperidinol Metabolites.
ChemMedChem
; 18(10): e202300030, 2023 05 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36892179
20.
European Medicinal Chemistry Leaders in Industry (EMCL) - On the Status and Future of Medicinal Chemistry Research in Europe.
ChemMedChem
; 18(13): e202300127, 2023 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37276375