Pesquisa | BVS Integralidade em Saúde

1.

A UK framework for the assessment and integration of different scientific evidence streams in chemical risk assessment.

Doerr, Barbara; Botham, Phil; Clare, Gill; Gott, David; Gowers, Alison; Guercio, Valentina; Loizou, George; Lovell, David P; Pearce, Neil; Rushton, Lesley; Toledano, Mireille; Wallace, Heather M; Boobis, Alan R.

Regul Toxicol Pharmacol ; 151: 105652, 2024 Jun 03.

Artigo em Inglês | MEDLINE | ID: mdl-38839030

2.

Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment.

Najjar, Abdulkarim; Punt, Ans; Wambaugh, John; Paini, Alicia; Ellison, Corie; Fragki, Styliani; Bianchi, Enrica; Zhang, Fagen; Westerhout, Joost; Mueller, Dennis; Li, Hequn; Shi, Quan; Gant, Timothy W; Botham, Phil; Bars, Rémi; Piersma, Aldert; van Ravenzwaay, Ben; Kramer, Nynke I.

Arch Toxicol ; 96(12): 3407-3419, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-36063173

3.

Towards a mechanism-based approach for the prediction of nongenotoxic carcinogenic potential of agrochemicals.

Heusinkveld, Harm; Braakhuis, Hedwig; Gommans, Robin; Botham, Phil; Corvaro, Marco; van der Laan, Jan Willem; Lewis, Dick; Madia, Federica; Manou, Irene; Schorsch, Frédéric; Wolterink, Gerrit; Woutersen, Ruud; Corvi, Raffaella; Mehta, Jyotigna; Luijten, Mirjam.

Crit Rev Toxicol ; 50(9): 725-739, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-33236972

4.

Finding synergies for the 3Rs - Repeated Dose Toxicity testing: Report from an EPAA Partners' Forum.

Laroche, Charles; Annys, Erwin; Bender, Hans; Botelho, Danielle; Botham, Phil; Brendler-Schwaab, Susanne; Clayton, Rick; Corvaro, Marco; Dal Negro, Gianni; Delannois, Frédérique; Dent, Matt; Desaintes, Christian; Desprez, Bertrand; Dhalluin, Stephane; Hartmann, Andreas; Hoffmann-Doerr, Simone; Hubesch, Bruno; Irizar, Amaia; Manou, Irene; Müller, Boris P; Nadzialek, Stephanie; Prieto, Pilar; Rasenberg, Mike; Roggeband, Rob; Rowan, Tim G; Schutte, Katrin; van de Water, Bob; Westmoreland, Carl; Whelan, Maurice; Wilschut, Annette; Zvonimir, Zvonar; Cronin, Mark T D.

Regul Toxicol Pharmacol ; 108: 104470, 2019 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-31479718

5.

Relevance of the 1-year dog study in assessing human health risks for registration of pesticides. An update to include pesticides registered in Japan.

Kobel, Werner; Fegert, Ivana; Billington, Richard; Lewis, Richard; Bentley, Karin; Langrand-Lerche, Carole; Botham, Phil; Sato, Masako; Debruyne, Eric; Strupp, Christian; van Ravenzwaay, Bennard.

Crit Rev Toxicol ; 44(10): 842-8, 2014 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-25198386

6.

The new normal chemical landscape: the future of risk assessment toward optimum consumer safety.

Osborne, Olivia J; Boobis, Alan; Botham, Phil; Price, Shirley Christine; Kuhnle, Gunter C; Mulholland, Cath; Potter, Claire; Gott, David.

Toxicol Res (Camb) ; 13(2): tfae016, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38450177

7.

A 1-year toxicity study in dogs is no longer a scientifically justifiable core data requirement for the safety assessment of pesticides.

Kobel, Werner; Fegert, Ivana; Billington, Richard; Lewis, Richard; Bentley, Karin; Bomann, Werner; Botham, Phil; Stahl, Bernhard; Ravenzwaay, Bennard van; Spielmann, Horst.

Crit Rev Toxicol ; 40(1): 1-15, 2010 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-19848553

8.

Guidance for the classification of carcinogens under the Globally Harmonised System of Classification and Labelling of Chemicals (GHS).

McGregor, Douglas; Boobis, Alan; Binaglia, Marco; Botham, Phil; Hoffstadt, Laurence; Hubbard, Sue; Petry, Thomas; Riley, Anthony; Schwartz, Dirk; Hennes, Christa.

Crit Rev Toxicol ; 40(3): 245-85, 2010 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-20014893

9.

The ECVAM international validation study on in vitro tests for acute skin irritation: report on the validity of the EPISKIN and EpiDerm assays and on the Skin Integrity Function Test.

Spielmann, Horst; Hoffmann, Sebastian; Liebsch, Manfred; Botham, Phil; Fentem, Julia H; Eskes, Chantra; Roguet, Roland; Cotovio, José; Cole, Thomas; Worth, Andrew; Heylings, Jon; Jones, Penny; Robles, Catherine; Kandárová, Helena; Gamer, Armin; Remmele, Marina; Curren, Rodger; Raabe, Hans; Cockshott, Amanda; Gerner, Ingrid; Zuang, Valérie.

Altern Lab Anim ; 35(6): 559-601, 2007 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-18186667

10.

An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the second FRAME Toxicity Committee (1991).

Combes, Robert; Balls, Michael; Bansil, Lee; Barratt, Martin; Bell, David; Botham, Phil; Broadhead, Caren; Clothier, Richard; George, Elizabeth; Fentem, Julia; Jackson, Michael; Indans, Ian; Loizu, Georg; Navaratnam, Vyra; Pentreath, Victor; Phillips, Barry; Stemplewski, Henry; Stewart, Jane.

Altern Lab Anim ; 30(4): 365-406, 2002.

Artigo em Inglês | MEDLINE | ID: mdl-12234245

11.

Interlaboratory validation of 1% pluronic l92 surfactant as a suitable, aqueous vehicle for testing pesticide formulations using the murine local lymph node assay.

Boverhof, Darrell R; Wiescinski, Connie M; Botham, Phil; Lees, David; Debruyne, Eric; Repetto-Larsay, Marina; Ladics, Gregory; Hoban, Denise; Gamer, Armin; Remmele, Marina; Wang-Fan, Weizheng; Ullmann, Ludwig G; Mehta, Jyotigna; Billington, Richard; Woolhiser, Michael R.

Toxicol Sci ; 105(1): 79-85, 2008 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-18556666

12.

Why laboratory rats are here to stay.

Botham, Phil; Purchase, Iain.

New Sci ; 134(1819): 29-30, 1992 May 02.

Artigo em Inglês | MEDLINE | ID: mdl-11659493

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