1.
Org Lett
; 10(23): 5321-4, 2008 Dec 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19006319
RESUMO
Rapid access to highly functionalized alkylidene cyclohexanols through a one-pot desymmetrizing hydroformylation/carbonyl ene cyclization starting from simple bisalkenylcarbinols is reported. Mechanistic insight into the carbonyl ene reaction is given, highlighting the importance of hyperconjugative substituent effects.
Assuntos
Alcenos/química , Cicloexanóis/química , Ciclização , Ésteres/química , Compostos Ferrosos/química , Cinética , Metalocenos , Metanol/química
2.
J Am Chem Soc
; 126(33): 10244-5, 2004 Aug 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15315427
RESUMO
Desymmetrizing hydroformylation of bisalkenyl- and bisallylcarbinols could be achieved employing a chiral substrate-bound catalyst-directing group (o-DPPF) with excellent levels of diastereotopic alkene face and diastereotopic alkene group discrimination to give bifunctionalized chiral aldehydes in enantiomerically pure form.