Detalhe da pesquisa
1.
The NIH Somatic Cell Genome Editing program.
Nature
; 592(7853): 195-204, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33828315
2.
Gene-targeted therapies: Overview and implications.
Am J Med Genet C Semin Med Genet
; 193(1): 13-18, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36864710
3.
Moving away from one disease at a time: Screening, trial design, and regulatory implications of novel platform technologies.
Am J Med Genet C Semin Med Genet
; 193(1): 30-43, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36738469
4.
The 8,5'-cyclopurine-2'-deoxynucleosides: candidate neurodegenerative DNA lesions in xeroderma pigmentosum, and unique probes of transcription and nucleotide excision repair.
DNA Repair (Amst)
; 7(7): 1168-79, 2008 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18495558
5.
Do all of the neurologic diseases in patients with DNA repair gene mutations result from the accumulation of DNA damage?
DNA Repair (Amst)
; 7(6): 834-48, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18339586
6.
Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: implications for alcohol-related carcinogenesis.
Mutat Res
; 664(1-2): 77-83, 2009 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19428384
7.
The Bespoke Gene Therapy Consortium: facilitating development of AAV gene therapies for rare diseases.
Nat Rev Drug Discov
; 23(3): 157-158, 2024 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38321319
8.
ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain.
DNA Repair (Amst)
; 6(11): 1698-707, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17706468
9.
The oxidatively induced DNA lesions 8,5'-cyclo-2'-deoxyadenosine and 8-hydroxy-2'-deoxyadenosine are strongly resistant to acid-induced hydrolysis of the glycosidic bond.
Mech Ageing Dev
; 128(9): 494-502, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17692895
10.
The case for 8,5'-cyclopurine-2'-deoxynucleosides as endogenous DNA lesions that cause neurodegeneration in xeroderma pigmentosum.
Neuroscience
; 145(4): 1407-17, 2007 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17184928
11.
Polyamines stimulate the formation of mutagenic 1,N2-propanodeoxyguanosine adducts from acetaldehyde.
Nucleic Acids Res
; 33(11): 3513-20, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15972793
12.
Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N2-ethyl-2'-deoxyguanosine.
Nucleic Acids Res
; 32(18): 5685-92, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15498925
13.
Hip resurfacing: a large, US single-surgeon series.
Bone Joint J
; 98-B(1 Suppl A): 10-3, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26733633
14.
Local morphine withdrawal increases c-fos gene, Fos protein, and oxytocin gene expression in hypothalamic magnocellular neurosecretory cells.
J Neurosci
; 20(3): 1272-80, 2000 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-10648731
15.
A single 8,5'-cyclo-2'-deoxyadenosine lesion in a TATA box prevents binding of the TATA binding protein and strongly reduces transcription in vivo.
DNA Repair (Amst)
; 1(11): 967-75, 2002 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-12531024
16.
Insulin-like growth factor II messenger ribonucleic acids are synthesized in the choroid plexus of the rat brain.
Mol Endocrinol
; 2(1): 47-54, 1988 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-3398842
17.
Growth hormone dependence of somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II messenger ribonucleic acids.
Mol Endocrinol
; 1(3): 233-42, 1987 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-3453890
18.
The past, present, and future of modeling Cockayne Syndrome - A commentary on "Rat Model of Cockayne Syndrome Neurological Disease".
DNA Repair (Amst)
; 88: 102788, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32058278
19.
DNA damage, repair, and antioxidant systems in brain regions: a correlative study.
Free Radic Biol Med
; 28(5): 779-85, 2000 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-10754274
20.
Estrogen modulation of mRNA levels for the two forms of glutamic acid decarboxylase (GAD) in female rat brain.
J Comp Neurol
; 360(4): 685-97, 1995 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-8801259