Detalhe da pesquisa
1.
Identification of 2-aminothiazolobenzazepine metabolites in human, rat, dog, and monkey microsomes by ion-molecule reactions in linear quadrupole ion trap mass spectrometry.
Drug Metab Dispos
; 43(3): 358-66, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25547868
2.
Seizure reduction in TSC2-mutant mouse model by an mTOR catalytic inhibitor.
Ann Clin Transl Neurol
; 10(10): 1790-1801, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37545094
3.
Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes.
J Med Chem
; 66(13): 9095-9119, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37399505
4.
Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem
; 65(2): 1206-1224, 2022 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34734694
5.
Elucidation of a novel bioactivation pathway of a 3,4-unsubstituted isoxazole in human liver microsomes: formation of a glutathione adduct of a cyanoacrolein derivative after isoxazole ring opening.
Drug Metab Dispos
; 39(2): 302-11, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21045198
6.
In vitro metabolism studies of nomifensine monooxygenation pathways: metabolite identification, reaction phenotyping, and bioactivation mechanism.
Drug Metab Dispos
; 38(10): 1767-78, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20595377
7.
Identification of multiple glutathione conjugates of 8-amino- 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate (nomifensine) in liver microsomes and hepatocyte preparations: evidence of the bioactivation of nomifensine.
Drug Metab Dispos
; 38(1): 46-60, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19812352
8.
Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders.
J Med Chem
; 63(3): 1068-1083, 2020 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31955578
9.
Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood-Brain Barrier Measured by Quantitative Targeted Proteomics.
Clin Pharmacol Ther
; 106(1): 228-237, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30673124