Detalhe da pesquisa
1.
Central Nervous System Delivery of the Catalytic Subunit of DNA-Dependent Protein Kinase Inhibitor Peposertib as Radiosensitizer for Brain Metastases.
J Pharmacol Exp Ther
; 381(3): 217-228, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35370138
2.
Central Nervous System Distribution of the Ataxia-Telangiectasia Mutated Kinase Inhibitor AZD1390: Implications for the Treatment of Brain Tumors.
J Pharmacol Exp Ther
; 383(1): 91-102, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36137710
3.
Brain Distribution of Berzosertib: An Ataxia Telangiectasia and Rad3-Related Protein Inhibitor for the Treatment of Glioblastoma.
J Pharmacol Exp Ther
; 379(3): 343-357, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34556535
4.
Delivery versus Potency in Treating Brain Tumors: BI-907828, a MDM2-p53 Antagonist with Limited BBB Penetration but Significant In Vivo Efficacy in Glioblastoma.
Mol Cancer Ther
; 23(1): 47-55, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37828724
5.
Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization.
Sci Transl Med
; 16(734): eadj5962, 2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38354228
6.
Bystander effects, pharmacokinetics, and linker-payload stability of EGFR-targeting antibody-drug conjugates Losatuxizumab vedotin and Depatux-M in glioblastoma models.
Clin Cancer Res
; 2024 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38743766
7.
Differential Distribution of the DNA-PKcs Inhibitor Peposertib Selectively Radiosensitizes Patient-derived Melanoma Brain Metastasis Xenografts.
Mol Cancer Ther
; 23(5): 662-671, 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38224566
8.
WSD-0922, a novel brain-penetrant inhibitor of epidermal growth factor receptor, promotes survival in glioblastoma mouse models.
Neurooncol Adv
; 5(1): vdad066, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37324218
9.
RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma.
Neuro Oncol
; 24(8): 1261-1272, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35231103
10.
Preclinical modeling in glioblastoma patient-derived xenograft (GBM PDX) xenografts to guide clinical development of lisavanbulin-a novel tumor checkpoint controller targeting microtubules.
Neuro Oncol
; 24(3): 384-395, 2022 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34232318
11.
Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy.
Sci Adv
; 8(17): eabl6339, 2022 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35486732
12.
Multimodal platform for assessing drug distribution and response in clinical trials.
Neuro Oncol
; 24(1): 64-77, 2022 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34383057
13.
Convection enhanced delivery of EGFR targeting antibody-drug conjugates Serclutamab talirine and Depatux-M in glioblastoma patient-derived xenografts.
Neurooncol Adv
; 4(1): vdac130, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36071925
14.
Experimental design of preclinical experiments: number of PDX lines vs subsampling within PDX lines.
Neuro Oncol
; 23(12): 2066-2075, 2021 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34107029
15.
Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks.
Cancer Res
; 81(14): 3930-3941, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34016623
16.
Heterogeneous delivery across the blood-brain barrier limits the efficacy of an EGFR-targeting antibody drug conjugate in glioblastoma.
Neuro Oncol
; 23(12): 2042-2053, 2021 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34050676
17.
Temozolomide Sensitizes MGMT-Deficient Tumor Cells to ATR Inhibitors.
Cancer Res
; 79(17): 4331-4338, 2019 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31273061
18.
Molecular profiling of long-term IDH-wildtype glioblastoma survivors.
Neuro Oncol
; 21(11): 1458-1469, 2019 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31346613
19.
Patient-Derived Xenograft Models of Colorectal Cancer: Procedures for Engraftment and Propagation.
Methods Mol Biol
; 1765: 307-314, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29589317
20.
Persistent mitochondrial hyperfusion promotes G2/M accumulation and caspase-dependent cell death.
PLoS One
; 9(3): e91911, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24632851